Cocaine Addiction

One of the most notorious recreational drugs in the world is cocaine, a powerful stimulant that is most commonly injected, smoked, or snorted. Cocaine is the second most popular illegal substance worldwide, with at least 35 million Americans over the age of 12 having admitted to using the drug.

While cocaine abuse is a difficult addiction to break, there is hope.

Recognizing Cocaine Addiction

Cocaine is a stimulant, meaning that most people on the drug will be overly excited and confident. Some signs of cocaine addiction include:

  • Track marks from shooting up (or other signs from snorting or smoking)
  • Drug paraphernalia (hypodermic needles, baggies with residue, etc.)
  • Unexpected episodes of excitement and confidence
  • Paranoid episodes
  • Financial problems because of increased drug use
  • Abnormal sleep patterns

To get treatment for cocaine addiction, it’s important to work with a reputable rehabilitation center that understands this drug and its impacts.

Cocaine Addiction Treatment

At True Recovery, we offer unique treatment options for cocaine abuse, including an intensive outpatient treatment program (IOP) that takes an individualized, holistic approach to cocaine addiction counseling and recovery.

We accept the majority of private insurance plans, and we can verify your coverage in as soon as an hour.

The True Recovery Difference

There are many treatment centers throughout Orange County that offer cocaine addiction recovery, but there are very few that are as extensive and unique as True Recovery. To us, you’re not just a number.

You are an individual who deserves a personalized treatment plan focused on your goals. Through our many therapy programs, we help you refocus your energy on your passions, hobbies, and goals to grow beyond substance use. Our small caseloads allow us to focus on you, and only you, while addressing your unique needs.

If you or someone you know has a cocaine addiction, don’t let it become more of a problem than it already is. Fill out our contact form or call today and speak with an admissions counselor right away.


Despite the well-known dangers that cocaine use presents, it remains the second most commonly abused drug in the world behind only marijuana. Cocaine is an alkaloid extracted from coca shrubs indigenous to South America that has a long history of both medical and recreational use.

Cocaine is used medically for its local anesthetic properties, and recreationally for its intense euphoric and stimulant high in which it produces when insufflated or injected.

Cocaine overdose deaths remain a significant factor in the ongoing drug overdose epidemic in the United States.

Cocaine Pharmacology

Cocaine has profound effects on the central nervous system and as a local anesthetic. Cocaine acts as a local anesthetic by blocking sodium channels contained in nerve cells.

In doing so, cocaine blocks nerve impulses from traveling from the nerve cell to the brain. This results in cocaine’s ability to numb areas of the body in which it is applied.

Cocaine’s effects on the central nervous system, however, are largely responsible for the extremely addictive nature of the substance. Cocaine acts as a reuptake-inhibitor of the neurotransmitters dopamine and norepinephrine. When these neurotransmitters are in excess in the brain, the brain responds naturally by removing them for later use.

This “removal” is known as the brain’s reuptake mechanism. A reuptake-inhibitor, such as cocaine, blocks the brain’s reuptake mechanism, thus allowing high concentrations of both dopamine and norepinephrine to accumulate in the brain.

Short-Term Effects of Cocaine

The primary effect of cocaine’s ability to act as a reuptake-inhibitor of dopamine causes the brain’s reward circuit to be flooded with the neurotransmitter. This, in turn, leads to an intense euphoria felt by the user and many of cocaine’s addictive properties. This euphoria is often described as a powerful sense of invincibility and general well being.

Cocaine also acts as a strong stimulant to the central nervous system. This results in the user feeling a burst of energy and enthusiasm. The user will often become very talkative and courageous. Cocaine’s ability to elicit energy can, in turn, cause the user to experience anxiety and/or paranoia in higher doses, sometimes resulting in violent behavior.

Cocaine, like the majority of other stimulants, has several effects on mental function. Cocaine causes the user to have an intense level of concentration and hyper focus far above the normal baseline.

This can cause the user to become fixated on a specific goal, idea, or action. Cocaine has been demonstrated to increase the function of working memory in the user as well. Finally, the user will have a decreased desire to sleep while on cocaine.

Cocaine’s ability to act as a reuptake-inhibitor of the neurotransmitter norepinephrine also produces several effects in the user. Cocaine causes the user to experience increased blood pressure and breathing during the duration of its action. This is the result of tachycardia, which is the abnormally rapid heart rate that cocaine induces.

This effect also typically can lead to tremors in the user. Like the majority of other stimulants, cocaine typically causes insomnia and suppression of appetite in users.

Long-term effects of cocaine addiction

Cocaine addiction causes several long-term health problems that stem as a direct result of both the drug itself and the lifestyle in which typically accompanies it. As mentioned, cocaine causes several circuit changes to the brain that result in severe mood swings and depression in absence of the drug.

Chronic cocaine use also causes sensitization, which is when increasingly smaller amounts of the drug produce negative side effects, such as convulsions, anxiety, and others. Sensitization to the negative side effects of cocaine coupled with tolerance to the pleasurable effects can often times lead to an overdose in users.

Cocaine has negative effects of several major organs. Cocaine has been demonstrated to be toxic to the heart and cardiovascular system, including causing inflammation of the heart. The appetite suppression effects of cocaine typically result in drastic weight loss in chronic users that can prove to be dangerous.

Cocaine increases the likelihood of stroke and seizures in chronic users. Bleeding in the brain has also been reported as a direct result of long-term cocaine abuse.

Along with the above-mentioned long-term effects of cocaine use, several other negative effects arise depending on the user’s preference of route of administration. Those who snort cocaine regularly are at a great risk of losing their sense of smell, and having many other chronic problems such as nosebleeds, runny nose, and deviated septum.

Users who smoke crack run the risk of developing acute pulmonary syndrome commonly nicknamed “crack lung”. This painful condition causes inflammation of the lungs and severe discomfort in chronic users.

Users who inject cocaine greatly increase the chances of developing life-threatening infections, including contraction of HIV and hepatitis-C. Intravenous users also run the risk of abscesses, collapsed veins, and significant damage to the cardiovascular system.

Forms of Cocaine and Their Use

Cocaine is a naturally occurring alkaloid that is found in and extracted from the coca plant. The method used to ingest cocaine typically corresponds with the form in which the user has obtained.

The leaves of the coca plant, which contain approximately 0.4-0.8% cocaine content per leaf, have historically been chewed in regions where the plant is indigenous. This method of use, however, is quite uncommon in the rest of the world.

Powder cocaine is the most commonly used form of cocaine in the world. It is comprised of cocaine hydrochloride, along with invariably some form of cutting agent. Cocaine hydrochloride is water soluble, which accounts for powder cocaine’s popularity.

Its water-soluble nature is what allows powder cocaine to be snorted, mixed in water and injected, or rubbed on the gums for oral absorption. Cocaine hydrochloride, however, cannot be smoked.

Crack cocaine is the common name for the form of cocaine that can be smoked. Cocaine hydrochloride decomposes at the high temperatures necessary to smoke it, and therefore cannot be smoked. Reacting cocaine hydrochloride with basic substances such as baking soda allows the hydrochloric acid to escape, ultimately yielding crack cocaine.

The resulting crack cocaine rocks vaporize much more readily than powder cocaine, allowing them to be smoked without decomposing the cocaine alkaloid.

Cocaine Duration of Effect, Half-Life, and Elimination Time from the Body

The duration of cocaine’s effect on the user (how long the high lasts) varies on the route of administration. When taken orally, the duration of cocaine’s effect on the user is approximately an hour long. When cocaine is snorted, the effects last typically around half an hour.

When cocaine/crack is smoked or freebased, the duration of effect is much shorter, usually lasting about ten minutes. Injecting cocaine provides the user with the shortest (but strongest) duration of effect, only lasting about five minutes.

Cocaine has a half-life of approximately one hour. In other words, the amount of cocaine in the user’s body decreases by one half approximately every hour.

Cocaine use can typically be detected by urine drug tests for approximately two to four days after the last use of the drug. This number, however, increases if the user is a chronic user with long binge periods.

Cocaine Overdose

Cocaine poisoning and overdose is a very real phenomenon that often times results in death. While the opioid/heroin overdoses continue to dominate national headlines, cocaine overdose deaths have increased every year since 2010.

Preliminary data from 2017 states that over 14,500 people in the United States lost their lives to a Cocaine overdose.

Cocaine overdoses can be broken down into three distinct phases. Unlike heroin and many other drugs, the first phase of a cocaine overdose is almost indistinguishable to the user. The side-effects of the first phase of a cocaine overdose are essentially the normal effects the user gets from cocaine use.

Thus, the majority of users will not realize they have overdosed during the initial phase of a cocaine overdose.

The second phase of cocaine overdose is much more unpleasant for the user. At this point, they will realize something is terribly wrong. The central nervous system of the user will essentially go into overdrive, leading to severe heart palpations, headaches, nausea, and vomiting.

Seizures are also common during this phase of a cocaine overdose. Finally, breathing will become more difficult for the user.

The third and final phase of cocaine overdose results in death. The overstimulation of the central nervous system during the second phase eventually leads to the system shutting down in the final phase. Once the central nervous system shuts down, the circulatory and respiratory systems cease to function.

Without medical intervention prior to the third and final phase of Cocaine overdose, the overdose will result in death.

Cocaine Tolerance and Addiction

Chronic cocaine abuse leads to tolerance to the effects in which it produces in the user. Tolerance refers to the phenomenon where increasing amounts of the drug need to be used in order to achieve the same effect as previously experienced.

Cocaine dependence results from a wide range of complex adaptive changes that occur in the brain to counter the chronic drug use.

Cocaine addiction is the result of both structural and biochemical changes to the brain that occurs through repeated abuse of the drug. Cocaine addiction is largely caused by the overexpression of the protein delta-FosB in response to repeated use.

Delta-FosB has been implicated in practically every form of behavioral and drug-induced addictions, including cocaine.

Cocaine has been shown repeatedly to cause a strong physiological addiction in chronic users. The intense desire and craving to use cocaine often result in drug-seeking behavior that continues despite growing consequences. In lab animals, for example, cocaine has been shown to be preferred over food, water, and sex.

When provided with unlimited access to the drugs, the majority of animals will use it until they either overdose or die of starvation. In a similar manner, chronic users of cocaine will often use until they are in financial ruin or their physical health deteriorates.

Cocaine Withdrawal Syndrome

Chronic cocaine abuse and subsequent dependence results in a defined cocaine withdrawal syndrome when users cease using. This withdrawal syndrome results from the adaptive changes the body has made to chronic cocaine use that make cocaine physically and physiologically addictive.

Cocaine withdrawal syndrome can be broken down into two distinct phases, followed by a post-acute withdrawal syndrome that will be covered in the next section.

The first phase of cocaine withdrawal syndrome is commonly referred to as the “crash” phase. This name derives from the crash the user experiences in the absence of both physical and mental surge of energy cocaine delivers that they had been accustomed to.

This phase typically results in a reversal of many of the common effects of cocaine use. Exhaustion and a strong desire to sleep long hours often occurs during this phase.

A surge in appetite compared to during a cocaine binge also is commonly experienced. The lack of euphoria the user had grown accustomed to will be typically replaced by irritability, feelings of depression, and general restlessness.

Unlike most other drug withdrawals, the first phase of cocaine use is often associated with an absence of drug cravings. This phase starts a few hours after the last use and continues for a few days.

The second phase of cocaine withdrawal syndrome begins a few days after the last use and lasts up to a few weeks. This phase is defined by the return of strong cravings and obsessions to use cocaine.

Therefore, the risk of relapse is highest during this phase of withdrawal. The intense focus and increased working memory associated with cocaine use typically gives way to an inability to concentrate and trouble with memory.

A general feeling of lethargy and depression is often accompanied with this phase of withdrawal. General sleep disturbances are also common during this phase. Finally, anxiety and mood swings are typically encountered during this phase of withdrawal.

Post-acute Withdrawal Syndrome (PAWS) and Cocaine

Once the initial cocaine withdrawal syndrome has passed, a subsequent syndrome with a defined set of symptoms tends to follow known as post-acute withdrawal syndrome (PAWS).

While these symptoms typically are not as severe as the initial withdrawal period, the long duration in which they are experienced makes them a very difficult challenge to overcome in obtaining long-term sobriety. Post-acute withdrawal syndrome typically begins after the first few weeks and can last several months.

Post-acute withdrawal syndrome occurs due to the adaptive changes to the central nervous system that occurs in response to chronic cocaine abuse. These changes, unfortunately, require extended periods of abstinence time to fully heal.

A common example of this phenomenon is the difficulty many people in early sobriety experience of feeling happiness during activities the brain normally would reward for, such as a nice meal.

This is the result of overstimulation of the brain’s reward system by chronic drug use.
Common symptoms of post-acute withdrawal syndrome include the return of some of the original withdrawal symptoms, such as sleep disturbances and depression.

Cravings and obsessions to use cocaine are also very common during this period, particularly in response to a stimuli that may remind the user of past drug use.

One study found that impulse control in recovering cocaine addicts took greater than a month to show any sort of improvement.

Treatment for Cocaine Addiction

There is currently no pharmacological treatment for cocaine addiction. As mentioned, cocaine causes adaptive changes to the brain that can take significant periods of abstinence in order to heal.

The cravings and obsessions to use during the initial cocaine withdrawal period typically make achieving long-term sobriety incredibly difficult for the cocaine addict.

Attending an in-patient treatment center increases the odds of successfully making it through this difficult time period. Recovery programs, such as Cocaine Anonymous, greatly aid in achieving long-term sobriety through the post-acute withdrawal period and beyond.

Final Note

If you are ready to take the next step in your recovery journey, we encourage you to contact us today. Our Admissions Counselors are available 24/7 at (866) 399-6528, or you can fill out our confidential contact form here.